Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Brighton & Hove Albion v Southampton
American Express Stadium
Friday, 3 p.m. ET / 8 p.m. UK
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Pervis Estupiñán | CB Igor Julio | CB Jan Paul van Hecke | RB Joël Veltman
DM Yasin Ayari | DM Mats Wieffer
LW Kaoru Mitoma | AM João Pedro | RW Georginio Rutter
ST Danny Welbeck
Injury/suspension updates:
Carlos Baleba, M, suspension, due back Dec. 5
Lewis Dunk, D, calf, DOUBT
Jack Hinshelwood, M/D, knee, DOUBT
Ferdi Kadioglu, M/D, toe, DOUBT
Solly March, F/M, knee, OUT, estimated return Dec. 8
James Milner, M/D, hamstring, OUT, estimated return Dec. 8
Adam Webster, D, hamstring, OUT, estimated return Dec. 8
Latest Southampton team news
Expected Lineup:
GK Alex McCarthy
LB Ryan Fraser | CB Taylor Harwood-Bellis | CB Jack Stephens | CB Flynn Downes | RB Kyle Walker-Peters
LM Adam Armstrong | CM Joe Aribo | CM Mateus Fernandes | RM Tyler Dibling
ST Paul Onuachu
Injury/suspension updates:
Gavin Bazunu, G, achilles, OUT, estimated return Jan. 11
Jan Bednarek, D, knee, OUT, estimated return Dec. 7
Adam Lallana, M, hamstring, DOUBT
Paul Onuachu, F, undisclosed, DOUBT
Aaron Ramsdale, G, finger, OUT, estimated return Dec. 15
William Smallbone, M, hamstring, OUT, estimated return Dec. 15
Ross Stewart, F, calf, OUT, estimated return Dec. 7
Brentford v Leicester City
Gtech Community Stadium
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Brentford team news
Expected Lineup:
GK Mark Flekken
LB Keane Lewis-Potter | CB Nathan Collins | CB Ethan Pinnock | RB Sepp van den Berg
CM Vitaly Janelt | CM Mathias Jensen | CM Christian Nørgaard
FWL Mikkel Damsgaard | ST Yoane Wissa | FWR Bryan Mbeumo
Injury/suspension updates:
Kristoffer Ajer, D, foot, DOUBT
Josh Dasilva, M, knee, OUT, estimated return Jan. 14
Rico Henry, M/D, knee, DOUBT
Aaron Hickey, M/D, hamstring, OUT, estimated return May. 18
Gustavo Nunes, F/M, back, DOUBT
Latest Leicester City team news
Expected Lineup:
GK Mads Hermansen
LB Victor Kristiansen | CB Wout Faes | CB Caleb Okoli | RB James Justin
DM Wilfred Ndidi | DM Boubakary Soumaré
LW Stephy Mavididi | AM Facundo Buonanotte | RW Jordan Ayew
ST Jamie Vardy
Injury/suspension updates:
Fatawu Issahaku, F, knee, OUT, estimated return Aug. 25
Ricardo Pereira, D, hamstring, OUT, estimated return Mar. 15
Jakub Stolarczyk, G, ankle, OUT, estimated return Dec. 22
Harry Winks, M, groin, OUT, estimated return Dec. 3
Crystal Palace v Newcastle United
Selhurst Park
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Crystal Palace team news
Expected Lineup:
GK Dean Henderson
CB Trevoh Chalobah | CB Marc Guéhi | CB Maxence Lacroix
LM Tyrick Mitchell | CM Cheick Doucoure | CM Will Hughes | RM Daniel Muñoz
AM Eberechi Eze | AM Ismaïla Sarr
ST Jean-Philippe Mateta
Injury/suspension updates:
Eberechi Eze, F/M, hamstring, DOUBT
Matheus França, F/M, groin, OUT, estimated return Dec. 3
Daichi Kamada, F/M, suspension, due back Dec. 7
Eddie Nketiah, F, hamstring, OUT, estimated return Dec. 7
Chadi Riad, D, knee, OUT, estimated return Dec. 7
Adam Wharton, M, groin, OUT, estimated return Dec. 3
Latest Newcastle United team news
Expected Lineup:
GK Nick Pope
LB Lewis Hall | CB Dan Burn | CB Fabian Schär | RB Valentino Livramento
CM Joelinton | CM Bruno Guimaraes | CM Sean Longstaff
FWL Harvey Barnes | ST Alexander Isak | FWR Anthony Gordon
Injury/suspension updates:
Sven Botman, D, knee, OUT, estimated return Dec. 4
Bruno Guimaraes, M, lower body, DOUBT
Emil Krafth, D, collarbone, OUT, estimated return Jan. 4
Jamaal Lascelles, D, knee, OUT, estimated return Jan. 15
Joe Willock, M, leg, DOUBT
Nottingham Forest v Ipswich Town
The City Ground
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Nottingham Forest team news
Expected Lineup:
GK Matz Sels
LB Álex Moreno | CB Murillo | CB Nikola Milenkovic | RB Ola Aina
DM Nicolás Domínguez | DM Ryan Yates
LW Callum Hudson-Odoi | AM Morgan Gibbs-White | RW Joao Pedro
ST Chris Wood
Injury/suspension updates:
Elliot Anderson, M, foot, DOUBT
Anthony Elanga, F/M, undisclosed, DOUBT
Morgan Gibbs-White, F/M, ankle, DOUBT
Danilo Oliveira, M, ankle, OUT, estimated return Dec. 21
Ibrahim Sangaré, M, thigh, OUT, estimated return Jan. 25
Latest Ipswich Town team news
Expected Lineup:
GK Aro Muric
LB Leif Davis | CB Cameron Burgess | CB Dara O'Shea | RB Axel Tuanzebe
DM Jens Cajuste | DM Sam Morsy
LW Samuel Szmodics | AM Omari Hutchinson | RW Wes Burns
ST Liam Delap
Injury/suspension updates:
Nathan Broadhead, F, groin, DOUBT
Jacob Greaves, D, hamstring, DOUBT
George Hirst, F, knee, OUT, estimated return Dec. 3
Ben Johnson, D, thigh, DOUBT
Chiedozie Ogbene, F/M, achilles, OUT, estimated return May. 3
Kalvin Phillips, M, undisclosed, DOUBT
Cieran Slicker, G, undisclosed, OUT, estimated return Dec. 14
Wolverhampton Wanderers v AFC Bournemouth
Molineux Stadium
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Wolverhampton Wanderers team news
Expected Lineup:
GK José Sá
LB Rayan Aït-Nouri | CB Santiago Bueno | CB Toti Gomes | RB Nélson Semedo
DM João Gomes | DM Mario Lemina
LW Rodrigo Gomes | AM Matheus Cunha | RW Jean-Ricner Bellegarde
ST Jørgen Strand Larsen
Injury/suspension updates:
Santiago Bueno, D, undisclosed, DOUBT
Craig Dawson, D, undisclosed, DOUBT
Enso Gonzalez, F/M, knee, OUT, estimated return May. 3
Sasa Kalajdzic, F, knee, OUT, estimated return Jan. 15
Yerson Mosquera, D, knee, OUT, estimated return Aug. 15
Pablo Sarabia, F/M, calf, DOUBT
Boubacar Traoré, M, knee, OUT, estimated return Jan. 15
Latest AFC Bournemouth team news
Expected Lineup:
GK Kepa Arrizabalaga
LB Milos Kerkez | CB Marcos Senesi | CB Illia Zabarnyi | RB Adam Smith
DM Ryan Christie | DM Lewis Cook
LW Dango Ouattara | AM Justin Kluivert | RW Marcus Tavernier
ST Evanilson
Injury/suspension updates:
Julián Araujo, D, hamstring, OUT, estimated return Feb. 25
Alex Scott, M, knee, OUT, estimated return Dec. 21
Antoine Semenyo, F/M, suspension, due back Dec. 5
Luis Sinisterra, F/M, hamstring, DOUBT
West Ham United v Arsenal
London Stadium
Saturday, 12:30 p.m. ET / 5:30 p.m. UK
Latest West Ham United team news
Expected Lineup:
GK Lukasz Fabianski
LB Emerson | CB Max Kilman | CB Konstantinos Mavropanos | RB Aaron Wan-Bissaka
DM Lucas Paquetá | DM Tomás Soucek
LW Crysencio Summerville | AM Carlos Soler | RW Jarrod Bowen
ST Michail Antonio
Injury/suspension updates:
Niclas Füllkrug, F, calf, DOUBT
Mohammed Kudus, F/M, suspension, due back Dec. 3
Jean-Clair Todibo, D, hamstring, DOUBT
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Riccardo Calafiori | CB Gabriel Magalhaes | CB William Saliba | RB Jurriën Timber
CM Martin Ødegaard | CM Mikel Merino | CM Declan Rice
FWL Leandro Trossard | ST Gabriel Jesus | FWR Bukayo Saka
Injury/suspension updates:
Gabriel Magalhaes, D, undisclosed, DOUBT
Takehiro Tomiyasu, D, knee, OUT, estimated return Dec. 8
Ben White, D, knee, OUT, estimated return Jan. 15
Chelsea v Aston Villa
Stamford Bridge
Sunday, 8.30 a.m. ET / 1.30 p.m. UK
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Marc Cucurella | CB Levi Colwill | CB Wesley Fofana | RB Malo Gusto
DM Moisés Caicedo | DM Enzo Fernández
LW João Félix | AM Cole Palmer | RW Noni Madueke
ST Nicolas Jackson
Injury/suspension updates:
Malo Gusto, D, illness, DOUBT
Reece James, D, hamstring, OUT, estimated return Jan. 4
Pedro Neto, F/M, undisclosed, DOUBT
Latest Aston Villa team news
Expected Lineup:
GK Emiliano Martínez
LB Ian Maatsen | CB Diego Carlos | CB Pau Torres | RB Ezri Konsa
DM Ross Barkley | DM Youri Tielemans
LW John McGinn | AM Morgan Rogers | RW Leon Bailey
ST Ollie Watkins
Injury/suspension updates:
Amadou Onana, M, undisclosed, DOUBT
Jacob Ramsey, M, hamstring, DOUBT
Manchester United v Everton
Old Trafford
Sunday, 8.30 a.m. ET / 1.30 p.m. UK
Latest Manchester United team news
Expected Lineup:
GK André Onana
CB Matthijs de Ligt | CB Lisandro Martínez | CB Noussair Mazraoui
LM Diogo Dalot | CM Christian Eriksen | CM Manuel Ugarte | RM Amad Diallo
AM Alejandro Garnacho | AM Bruno Fernandes
ST Marcus Rashford
Injury/suspension updates:
Jonny Evans, D, undisclosed, DOUBT
Victor Lindelöf, D, groin, OUT, estimated return Dec. 1
Harry Maguire, D, calf, OUT, estimated return Dec. 1
Tyrell Malacia, D, knee, DOUBT
Lisandro Martínez, D, back, DOUBT
Leny Yoro, D, foot, OUT, estimated return Dec. 7
Latest Everton team news
Expected Lineup:
GK Jordan Pickford
LB Vitaliy Mykolenko | CB Jarrad Branthwaite | CB James Tarkowski | RB Ashley Young
DM Abdoulaye Doucouré | DM Idrissa Gueye
LW Iliman Ndiaye | AM Dwight McNeil | RW Jesper Lindstrom
ST Dominic Calvert-Lewin
Injury/suspension updates:
Armando Broja, F, ankle, DOUBT
Seamus Coleman, D, hamstring, DOUBT
James Garner, M, back, OUT, estimated return Dec. 22
Tim Iroegbunam, M, foot, OUT, estimated return Dec. 7
Youssef Chermiti, F, foot, OUT, estimated return Dec. 29
Tottenham Hotspur v Fulham
Tottenham Hotspur Stadium
Sunday, 8.30 a.m. ET / 1.30 p.m. UK
Latest Tottenham Hotspur team news
Expected Lineup:
GK Fraser Forster
LB Destiny Udogie | CB Ben Davies | CB Radu Dragusin | RB Pedro Porro
CM James Maddison | CM Yves Bissouma | CM Pape Matar Sarr
FWL Son Heung-Min | ST Dominic Solanke | FWR Dejan Kulusevski
Injury/suspension updates:
Rodrigo Bentancur, M, suspension, due back Dec. 26
Richarlison, F, hamstring, OUT, estimated return Dec. 15
Mikey Moore, F/M, illness, OUT, estimated return Dec. 12
Wilson Odobert, F/M, hamstring, OUT, estimated return Feb. 15
Cristian Romero, D, foot, OUT, estimated return Dec. 1
Micky van de Ven, D, hamstring, OUT, estimated return Dec. 8
Guglielmo Vicario, G, ankle, OUT, estimated return Feb. 25
Latest Fulham team news
Expected Lineup:
GK Bernd Leno
LB Antonee Robinson | CB Calvin Bassey | CB Issa Diop | RB Kenny Tete
DM Sasa Lukic | DM Andreas Pereira
LW Reiss Nelson | AM Emile Smith Rowe | RW Alex Iwobi
ST Raúl Jiménez
Injury/suspension updates:
Joachim Andersen, D, calf, DOUBT
Sander Berge, M, illness, DOUBT
Harrison Reed, M, knee, OUT, estimated return Dec. 29
Carlos Vinícius, F, undisclosed, DOUBT
Liverpool v Manchester City
Anfield
Sunday, 11:00 a.m. ET / 4 p.m. UK
Latest Liverpool team news
Expected Lineup:
GK Caoimhín Kelleher
LB Andrew Robertson | CB Ibrahima Konaté | CB Virgil van Dijk | RB Trent Alexander-Arnold
DM Ryan Gravenberch | DM Alexis Mac Allister
LW Cody Gakpo | AM Dominik Szoboszlai | RW Mohamed Salah
ST Darwin Núñez
Injury/suspension updates:
Alisson Becker, G, hamstring, OUT, estimated return Dec. 1
Conor Bradley, D, hamstring, DOUBT
Federico Chiesa, F/M, undisclosed, OUT, estimated return Dec. 7
Diogo Jota, F, upper body, OUT, estimated return Dec. 4
Ibrahima Konaté, D, foot, DOUBT
Kostas Tsimikas, D, ankle, OUT, estimated return Dec. 1
Latest Manchester City team news
Expected Lineup:
GK Ederson
LB Josko Gvardiol | CB Manuel Akanji | CB Nathan Aké | RB Kyle Walker
DM Matheus Nunes | DM Rico Lewis
LW Phil Foden | AM Kevin De Bruyne | RW Savinho
ST Erling Haaland
Injury/suspension updates:
Oscar Bobb, F/M, leg, OUT, estimated return Jan. 14
Rúben Dias, D, calf, DOUBT
Jérémy Doku, F/M, quadriceps, DOUBT
Rodri, M, knee, OUT, estimated return Jul. 1
Mateo Kovacic, M, undisclosed, OUT, estimated return Dec. 15
John Stones, D, undisclosed, DOUBT