Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Leicester City v Chelsea
King Power Stadium
Saturday, 7:30 a.m. ET / 12:30 p.m. UK
Latest Leicester City team news
Expected Lineup:
GK Mads Hermansen
LB Victor Kristiansen | CB Wout Faes | CB Jannik Vestergaard | RB James Justin
CM Wilfred Ndidi | CM Boubakary Soumaré | CM Harry Winks
FWL Stephy Mavididi | ST Jamie Vardy | FWR Jordan Ayew
Injury/suspension updates:
Jordan Ayew, F, knee, DOUBT
Facundo Buonanotte, F/M, suspension, due back Nov. 30
Patson Daka, F, ankle, DOUBT
Bobby De Cordova-Reid, F/M, lower leg, DOUBT
Fatawu Issahaku, F, knee, OUT, estimated return Aug. 25
Ricardo Pereira, D, hamstring, OUT, estimated return Mar. 15
Jakub Stolarczyk, G, ankle, OUT, estimated return Dec. 22
Jamie Vardy, F, back, DOUBT
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Marc Cucurella | CB Levi Colwill | CB Wesley Fofana | RB Malo Gusto
DM Moisés Caicedo | DM Enzo Fernández
LW Pedro Neto | AM Cole Palmer | RW Noni Madueke
ST Nicolas Jackson
Injury/suspension updates:
Wesley Fofana, D, undisclosed, DOUBT
Reece James, D, hamstring, DOUBT
Romeo Lavia, M, hamstring, DOUBT
Jadon Sancho, F/M, illness, DOUBT
AFC Bournemouth v Brighton & Hove Albion
Vitality Stadium
Saturday, 10 a.m. ET / 3 p.m. UK
Latest AFC Bournemouth team news
Expected Lineup:
GK Kepa Arrizabalaga
LB Milos Kerkez | CB Marcos Senesi | CB Illia Zabarnyi | RB Adam Smith
DM Tyler Adams | DM Lewis Cook
LW Marcus Tavernier | AM Justin Kluivert | RW Antoine Semenyo
ST Evanilson
Injury/suspension updates:
Julián Araujo, D, hamstring, OUT, estimated return Feb. 25
Ryan Christie, M, suspension, due back Nov. 30
Dango Ouattara, F/M, undisclosed, DOUBT
Alex Scott, M, knee, OUT, estimated return Dec. 21
Luis Sinisterra, F/M, hamstring, DOUBT
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Pervis Estupiñán | CB Igor Julio | CB Jan Paul van Hecke | RB Joël Veltman
DM Carlos Baleba | DM Jack Hinshelwood
LW Kaoru Mitoma | AM João Pedro | RW Simon Adingra
ST Danny Welbeck
Injury/suspension updates:
Yasin Ayari, M, foot, DOUBT
Carlos Baleba, M, knee, DOUBT
Lewis Dunk, D, calf, DOUBT
Jack Hinshelwood, M/D, knee, DOUBT
Ferdi Kadioglu, M/D, toe, OUT, estimated return Dec. 8
Solly March, F/M, knee, OUT, estimated return Dec. 8
James Milner, M/D, hamstring, OUT, estimated return Dec. 8
Adam Webster, D, hamstring, DOUBT
Arsenal v Nottingham Forest
Emirates Stadium
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Riccardo Calafiori | CB Gabriel Magalhaes | CB William Saliba | RB Jurriën Timber
CM Martin Ødegaard | CM Declan Rice | CM Thomas Partey
FWL Gabriel Martinelli | ST Kai Havertz | FWR Bukayo Saka
Injury/suspension updates:
Riccardo Calafiori, D, knee, DOUBT
Martin Ødegaard, F/M, ankle, DOUBT
Declan Rice, M, undisclosed, DOUBT
Bukayo Saka, F/M, undisclosed, DOUBT
Kieran Tierney, D, hamstring, DOUBT
Takehiro Tomiyasu, D, knee, DOUBT
Leandro Trossard, F/M, undisclosed, DOUBT
Ben White, D, knee, OUT, estimated return Dec. 27
Latest Nottingham Forest team news
Expected Lineup:
GK Matz Sels
LB Álex Moreno | CB Murillo | CB Nikola Milenkovic | RB Ola Aina
DM Elliot Anderson | DM Ryan Yates
LW Callum Hudson-Odoi | AM Morgan Gibbs-White | RW Anthony Elanga
ST Chris Wood
Injury/suspension updates:
Danilo Oliveira, M, ankle, OUT, estimated return Dec. 21
Ibrahim Sangaré, M, thigh, OUT, estimated return Dec. 4
Aston Villa v Crystal Palace
Villa Park
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Aston Villa team news
Expected Lineup:
GK Emiliano Martínez
LB Lucas Digne | CB Diego Carlos | CB Pau Torres | RB Ezri Konsa
DM Amadou Onana | DM Youri Tielemans
LW John McGinn | AM Morgan Rogers | RW Leon Bailey
ST Ollie Watkins
Injury/suspension updates:
Ross Barkley, M, undisclosed, DOUBT
Matty Cash, D, calf, DOUBT
Boubacar Kamara, M/D, undisclosed, DOUBT
Ezri Konsa, D, hip, DOUBT
Amadou Onana, M, undisclosed, DOUBT
Jacob Ramsey, M, hamstring, DOUBT
Pau Torres, D, strain, DOUBT
Latest Crystal Palace team news
Expected Lineup:
GK Dean Henderson
CB Trevoh Chalobah | CB Marc Guéhi | CB Maxence Lacroix
LM Tyrick Mitchell | CM Cheick Doucoure | CM Will Hughes | RM Daniel Muñoz
AM Ismaïla Sarr | AM Jeff Schlupp
ST Jean-Philippe Mateta
Injury/suspension updates:
Eberechi Eze, F/M, hamstring, DOUBT
Matheus França, F/M, groin, DOUBT
Daichi Kamada, F/M, suspension, due back Dec. 7
Jefferson Lerma, M, hamstring, DOUBT
Eddie Nketiah, F, hamstring, DOUBT
Chadi Riad, D, knee, DOUBT
Adam Wharton, M, groin, OUT, estimated return Dec. 3
Everton v Brentford
Goodison Park
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Everton team news
Expected Lineup:
GK Jordan Pickford
LB Vitaliy Mykolenko | CB Jarrad Branthwaite | CB James Tarkowski | RB Ashley Young
DM Abdoulaye Doucouré | DM Idrissa Gueye
LW Iliman Ndiaye | AM Dwight McNeil | RW Jesper Lindstrom
ST Dominic Calvert-Lewin
Injury/suspension updates:
Jarrad Branthwaite, D, groin, DOUBT
Armando Broja, F, ankle, OUT, estimated return Dec. 14
Seamus Coleman, D, hamstring, OUT, estimated return Dec. 1
James Garner, M, back, OUT, estimated return Dec. 1
Tim Iroegbunam, M, foot, DOUBT
Dwight McNeil, F/M, knee, DOUBT
Youssef Chermiti, F, foot, OUT, estimated return Dec. 29
Latest Brentford team news
Expected Lineup:
GK Mark Flekken
CB Nathan Collins | CB Ethan Pinnock | CB Sepp van den Berg
LM Keane Lewis-Potter | CM Mikkel Damsgaard | CM Vitaly Janelt | CM Mathias Jensen | RM Christian Nørgaard
ST Bryan Mbeumo | ST Yoane Wissa
Injury/suspension updates:
Kristoffer Ajer, D, foot, OUT, estimated return Nov. 30
Josh Dasilva, M, knee, OUT, estimated return Jan. 14
Rico Henry, M/D, knee, OUT, estimated return Nov. 30
Aaron Hickey, M/D, hamstring, OUT, estimated return May. 18
Bryan Mbeumo, F/M, undisclosed, DOUBT
Igor Thiago, F, knee, DOUBT
Gustavo Nunes, F/M, back, OUT, estimated return Nov. 30
Ethan Pinnock, D, undisclosed, DOUBT
Yoane Wissa, F/M, undisclosed, DOUBT
Fulham v Wolverhampton Wanderers
Craven Cottage
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Fulham team news
Expected Lineup:
GK Bernd Leno
LB Antonee Robinson | CB Joachim Andersen | CB Calvin Bassey | RB Kenny Tete
DM Sander Berge | DM Andreas Pereira
LW Reiss Nelson | AM Emile Smith Rowe | RW Alex Iwobi
ST Raúl Jiménez
Injury/suspension updates:
Sasa Lukic, M, shoulder, DOUBT
Carlos Vinícius, F, undisclosed, DOUBT
Latest Wolverhampton Wanderers team news
Expected Lineup:
GK José Sá
CB Santiago Bueno | CB Craig Dawson | CB Toti Gomes
LM Rayan Aït-Nouri | CM João Gomes | CM Mario Lemina | RM Nélson Semedo
AM Matheus Cunha | AM Pablo Sarabia
ST Jørgen Strand Larsen
Injury/suspension updates:
Enso Gonzalez, F/M, knee, OUT, estimated return May. 3
Hwang Hee-Chan, F, ankle, DOUBT
Sasa Kalajdzic, F, knee, OUT, estimated return Jan. 15
Bastien Meupiyou, M/D, undisclosed, DOUBT
Yerson Mosquera, D, knee, OUT, estimated return Aug. 15
Pablo Sarabia, F/M, calf, DOUBT
Boubacar Traoré, M, knee, OUT, estimated return Jan. 15
Manchester City v Tottenham Hotspur
Etihad Stadium
Saturday, 12:30 p.m. ET / 5:30 p.m. UK
Latest Manchester City team news
Expected Lineup:
GK Ederson
LB Josko Gvardiol | CB Manuel Akanji | CB Nathan Aké | RB Rico Lewis
DM Matheus Nunes
LM Phil Foden | CM Kevin De Bruyne | CM Bernardo Silva | RM Savinho
ST Erling Haaland
Injury/suspension updates:
Manuel Akanji, D, ankle, DOUBT
Oscar Bobb, F/M, leg, OUT, estimated return Jan. 14
Rúben Dias, D, undisclosed, DOUBT
Jérémy Doku, F/M, undisclosed, DOUBT
Phil Foden, F/M, undisclosed, DOUBT
Jack Grealish, F/M, undisclosed, DOUBT
Rodri, M, knee, OUT, estimated return Jul. 1
John Stones, D, undisclosed, DOUBT
Latest Tottenham Hotspur team news
Expected Lineup:
GK Guglielmo Vicario
LB Destiny Udogie | CB Ben Davies | CB Radu Dragusin | RB Pedro Porro
CM Dejan Kulusevski | CM Yves Bissouma | CM Pape Matar Sarr
FWL Son Heung-Min | ST Dominic Solanke | FWR Brennan Johnson
Injury/suspension updates:
Rodrigo Bentancur, M, suspension, due back Dec. 26
Richarlison, F, hamstring, OUT, estimated return Nov. 28
Mikey Moore, F/M, illness, DOUBT
Wilson Odobert, F/M, hamstring, OUT, estimated return Feb. 15
Micky van de Ven, D, hamstring, DOUBT
Timo Werner, F/M, groin, DOUBT
Southampton v Liverpool
St. Mary's Stadium
Sunday, 9 a.m. ET / 2 p.m. UK
Latest Southampton team news
Expected Lineup:
GK Alex McCarthy
LB Ryan Manning | CB Taylor Harwood-Bellis | CB Jack Stephens | CB Kyle Walker-Peters | RB Yukinari Sugawara
CM Flynn Downes | CM Mateus Fernandes | CM Adam Lallana
ST Cameron Archer | ST Adam Armstrong
Injury/suspension updates:
Gavin Bazunu, G, achilles, OUT, estimated return Jan. 11
Jan Bednarek, D, knee, OUT, estimated return Dec. 7
Flynn Downes, M, undisclosed, DOUBT
Ryan Fraser, F/M, undisclosed, DOUBT
Aaron Ramsdale, G, finger, OUT, estimated return Dec. 15
William Smallbone, M, hamstring, OUT, estimated return Nov. 29
Ross Stewart, F, calf, OUT, estimated return Nov. 29
Latest Liverpool team news
Expected Lineup:
GK Caoimhín Kelleher
LB Andrew Robertson | CB Ibrahima Konaté | CB Virgil van Dijk | RB Conor Bradley
DM Ryan Gravenberch | DM Alexis Mac Allister
LW Cody Gakpo | AM Curtis Jones | RW Mohamed Salah
ST Darwin Núñez
Injury/suspension updates:
Trent Alexander-Arnold, D, hamstring, OUT, estimated return Dec. 1
Alisson Becker, G, hamstring, DOUBT
Federico Chiesa, F/M, undisclosed, DOUBT
Harvey Elliott, F/M, foot, DOUBT
Diogo Jota, F, upper body, DOUBT
Virgil van Dijk, D, undisclosed, DOUBT
Ipswich Town v Manchester United
Portman Road
Sunday, 11:30 a.m. ET / 4:30 p.m. UK
Latest Ipswich Town team news
Expected Lineup:
GK Aro Muric
LB Leif Davis | CB Cameron Burgess | CB Dara O'Shea | CB Axel Tuanzebe | RB Ben Johnson
CM Jens Cajuste | CM Sam Morsy
AM Omari Hutchinson
ST Liam Delap
Injury/suspension updates:
Nathan Broadhead, F, groin, DOUBT
Wes Burns, F/M, undisclosed, DOUBT
Jacob Greaves, D, hamstring, DOUBT
Chiedozie Ogbene, F/M, achilles, OUT, estimated return May. 3
Cieran Slicker, G, undisclosed, DOUBT
Jack Taylor, M, undisclosed, DOUBT
Latest Manchester United team news
Expected Lineup:
GK André Onana
LB Noussair Mazraoui | CB Matthijs de Ligt | CB Lisandro Martínez | RB Diogo Dalot
DM Manuel Ugarte | DM Casemiro
LW Alejandro Garnacho | AM Bruno Fernandes | RW Amad Diallo
ST Rasmus Højlund
Injury/suspension updates:
Victor Lindelöf, D, groin, DOUBT
Harry Maguire, D, calf, DOUBT
Kobbie Mainoo, M, knee, DOUBT
Tyrell Malacia, D, knee, OUT, estimated return Dec. 1
Lisandro Martínez, D, hip, DOUBT
Luke Shaw, D, calf, DOUBT
Leny Yoro, D, foot, OUT, estimated return Nov. 28
Newcastle United v West Ham United
St. James' Park
Monday, 3 p.m. ET / 8 p.m. UK
Latest Newcastle United team news
Expected Lineup:
GK Nick Pope
LB Lewis Hall | CB Lloyd Kelly | CB Fabian Schär | RB Valentino Livramento
CM Bruno Guimaraes | CM Sean Longstaff | CM Joe Willock
FWL Joelinton | ST Alexander Isak | FWR Anthony Gordon
Injury/suspension updates:
Sven Botman, D, knee, OUT, estimated return Dec. 4
Dan Burn, D, suspension, due back Nov. 30
Anthony Gordon, F/M, hip, DOUBT
Jamaal Lascelles, D, knee, OUT, estimated return Jan. 15
Kieran Trippier, D, hamstring, DOUBT
Callum Wilson, F, back, DOUBT
Latest West Ham United team news
Expected Lineup:
GK Lukasz Fabianski
LB Emerson | CB Max Kilman | CB Jean-Clair Todibo | RB Aaron Wan-Bissaka
DM Guido Rodríguez
LM Crysencio Summerville | CM Lucas Paquetá | CM Tomás Soucek | RM Jarrod Bowen
ST Michail Antonio
Injury/suspension updates:
Niclas Füllkrug, F, calf, OUT, estimated return Nov. 30
Mohammed Kudus, F/M, suspension, due back Dec. 3