Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Manchester City v Everton
Etihad Stadium
Thursday, 12:30 p.m. GMT / 7:30 a.m. ET
Latest Manchester City team news
Expected Lineup:
GK Stefan Ortega
LB Rico Lewis | CB Manuel Akanji | CB Josko Gvardiol | RB Kyle Walker
DM Ilkay Gündogan
LM Jérémy Doku | CM Kevin De Bruyne | CM Phil Foden | RM Savinho
ST Erling Haaland
Injury/suspension updates:
Oscar Bobb, F/M, leg, OUT, estimated return Jan. 14
Rúben Dias, D, undisclosed, OUT, estimated return Jan. 19
Rodri, M, knee, OUT, estimated return Jul. 1
Ederson, G, undisclosed, DOUBT
Matheus Nunes, M, undisclosed, DOUBT
John Stones, D, undisclosed, DOUBT
Latest Everton team news
Expected Lineup:
GK Jordan Pickford
LB Vitaliy Mykolenko | CB Jarrad Branthwaite | CB James Tarkowski | RB Seamus Coleman
CM Abdoulaye Doucouré | CM Idrissa Gueye | CM Orel Mangala
FWL Iliman Ndiaye | ST Dominic Calvert-Lewin | FWR Jack Harrison
Injury/suspension updates:
James Garner, M, back, OUT, estimated return Jan. 9
Tim Iroegbunam, M, foot, OUT, estimated return Jan. 9
Dwight McNeil, F/M, knee, DOUBT
Ashley Young, M/D, suspension, due back Dec. 29
AFC Bournemouth v Crystal Palace
Vitality Stadium
Thursday, 3 p.m. GMT / 10 a.m. ET
Latest AFC Bournemouth team news
Expected Lineup:
GK Kepa Arrizabalaga
LB Milos Kerkez | CB Dean Huijsen | CB Illia Zabarnyi | RB Adam Smith
DM Ryan Christie | DM Lewis Cook
LW Enes Ünal | AM Justin Kluivert | RW Antoine Semenyo
ST Evanilson
Injury/suspension updates:
Julián Araujo, D, hamstring, OUT, estimated return Feb. 25
Alex Scott, M, knee, OUT, estimated return Jan. 11
Marcos Senesi, D, quadriceps, OUT, estimated return Mar. 15
Luis Sinisterra, F/M, hamstring, DOUBT
Marcus Tavernier, F/M, hamstring, OUT, estimated return Jan. 25
Latest Crystal Palace team news
Expected Lineup:
GK Dean Henderson
CB Trevoh Chalobah | CB Marc Guéhi | CB Maxence Lacroix
LM Tyrick Mitchell | CM Will Hughes | CM Jefferson Lerma | RM Daniel Muñoz
AM Eberechi Eze | AM Ismaïla Sarr
ST Jean-Philippe Mateta
Injury/suspension updates:
Eberechi Eze, F/M, foot, DOUBT
Matheus França, F/M, groin, OUT, estimated return Jan. 12
Chadi Riad, D, knee, DOUBT
Adam Wharton, M, groin, OUT, estimated return Jan. 26
Chelsea v Fulham
Stamford Bridge
Thursday, 3 p.m. GMT / 10 a.m. ET
Latest Chelsea team news
Expected Lineup:
GK Filip Jorgensen
LB Marc Cucurella | CB Tosin Adarabioyo | CB Levi Colwill | RB Malo Gusto
DM Moisés Caicedo | DM Enzo Fernández
LW João Félix | AM Cole Palmer | RW Noni Madueke
ST Christopher Nkunku
Injury/suspension updates:
Benoît Badiashile, D, undisclosed, OUT, estimated return Jan. 4
Wesley Fofana, D, hamstring, OUT, estimated return Dec. 30
Reece James, D, hamstring, OUT, estimated return Jan. 4
Romeo Lavia, M, undisclosed, DOUBT
Mykhailo Mudryk, F/M, not injury related, OUT, estimated return Jan. 25
Latest Fulham team news
Expected Lineup:
GK Bernd Leno
LB Antonee Robinson | CB Calvin Bassey | CB Issa Diop | RB Timothy Castagne
DM Tom Cairney | DM Sasa Lukic
LW Alex Iwobi | AM Andreas Pereira | RW Adama Traoré
ST Raúl Jiménez
Injury/suspension updates:
Sander Berge, M, ankle, DOUBT
Sasa Lukic, M, shoulder, DOUBT
Reiss Nelson, F/M, hamstring, OUT, estimated return Feb. 20
Harrison Reed, M, knee, OUT, estimated return Dec. 29
Emile Smith Rowe, M, leg, DOUBT
Kenny Tete, D, knee, OUT, estimated return Feb. 25
Newcastle United v Aston Villa
St. James' Park
Thursday, 3 p.m. GMT / 10 a.m. ET
Latest Newcastle United team news
Expected Lineup:
GK Martin Dúbravka
LB Lewis Hall | CB Dan Burn | CB Fabian Schär | RB Valentino Livramento
CM Joelinton | CM Bruno Guimaraes | CM Sandro Tonali
FWL Anthony Gordon | ST Alexander Isak | FWR Jacob Murphy
Injury/suspension updates:
Sven Botman, D, knee, DOUBT
Joelinton, F/M, bruise, DOUBT
Emil Krafth, D, collarbone, OUT, estimated return Jan. 4
Jamaal Lascelles, D, knee, OUT, estimated return Jan. 15
Nick Pope, G, knee, OUT, estimated return Jan. 12
Callum Wilson, F, hamstring, OUT, estimated return Feb. 1
Latest Aston Villa team news
Expected Lineup:
GK Emiliano Martínez
LB Lucas Digne | CB Ezri Konsa | CB Pau Torres | RB Matty Cash
DM Amadou Onana | DM Boubacar Kamara
LW Morgan Rogers | AM Youri Tielemans | RW John McGinn
ST Ollie Watkins
Injury/suspension updates:
Jacob Ramsey, M, hamstring, DOUBT
Diego Carlos, D, knee, DOUBT
Nottingham Forest v Tottenham Hotspur
The City Ground
Thursday, 3 p.m. GMT / 10 a.m. ET
Latest Nottingham Forest team news
Expected Lineup:
GK Matz Sels
LB Álex Moreno | CB Murillo | CB Nikola Milenkovic | RB Ola Aina
DM Elliot Anderson | DM Ryan Yates
LW Callum Hudson-Odoi | AM Morgan Gibbs-White | RW Anthony Elanga
ST Chris Wood
Injury/suspension updates:
Nicolás Domínguez, M, suspension, due back Dec. 29
Danilo Oliveira, M, ankle, OUT, estimated return Jan. 6
Ibrahim Sangaré, M, thigh, OUT, estimated return Jan. 25
Latest Tottenham Hotspur team news
Expected Lineup:
GK Fraser Forster
LB Destiny Udogie | CB Radu Dragusin | CB Archie Gray | RB Djed Spence
CM Dejan Kulusevski | CM Rodrigo Bentancur | CM Pape Matar Sarr
FWL Son Heung-Min | ST Dominic Solanke | FWR Brennan Johnson
Injury/suspension updates:
Ben Davies, D, hamstring, OUT, estimated return Dec. 29
Richarlison, F, hamstring, OUT, estimated return Jan. 12
Mikey Moore, F/M, illness, OUT, estimated return Jan. 4
Wilson Odobert, F/M, hamstring, OUT, estimated return Feb. 15
Cristian Romero, D, quadriceps, OUT, estimated return Jan. 12
Micky van de Ven, D, hamstring, OUT, estimated return Jan. 12
Guglielmo Vicario, G, ankle, OUT, estimated return Feb. 25
Southampton v West Ham United
St. Mary's Stadium
Thursday, 3 p.m. GMT / 10 a.m. ET
Latest Southampton team news
Expected Lineup:
GK Aaron Ramsdale
CB Jan Bednarek | CB Taylor Harwood-Bellis | CB Nathan Wood
LM Ryan Manning | CM Flynn Downes | CM Lesley Ugochukwu | RM Kyle Walker-Peters
AM Mateus Fernandes
ST Cameron Archer | ST Adam Armstrong
Injury/suspension updates:
Gavin Bazunu, G, achilles, OUT, estimated return Jan. 11
William Smallbone, M, hamstring, OUT, estimated return Jan. 12
Ross Stewart, F, calf, OUT, estimated return Jan. 12
Latest West Ham United team news
Expected Lineup:
GK Lukasz Fabianski
LB Emerson | CB Max Kilman | CB Konstantinos Mavropanos | RB Aaron Wan-Bissaka
DM Edson Álvarez
LM Mohammed Kudus | CM Carlos Soler | CM Tomás Soucek | RM Crysencio Summerville
ST Jarrod Bowen
Injury/suspension updates:
Michail Antonio, F, leg, OUT, estimated return Dec. 1
Lucas Paquetá, F/M, suspension, due back Dec. 29
Wolverhampton Wanderers v Manchester United
Molineux Stadium
Thursday, 5:30 p.m. GMT / 12:30 p.m. ET
Latest Wolverhampton Wanderers team news
Expected Lineup:
GK José Sá
CB Santiago Bueno | CB Toti Gomes | CB Matt Doherty
LM Rayan Aït-Nouri | CM João Gomes | CM Andre | RM Nélson Semedo
AM Goncalo Guedes | AM Matheus Cunha
ST Jørgen Strand Larsen
Injury/suspension updates:
Enso Gonzalez, F/M, knee, OUT, estimated return May. 3
Sasa Kalajdzic, F, knee, OUT, estimated return Jan. 15
Mario Lemina, M, undisclosed, DOUBT
Yerson Mosquera, D, knee, OUT, estimated return Aug. 15
Pablo Sarabia, F/M, calf, OUT, estimated return Jan. 6
Boubacar Traoré, M, knee, OUT, estimated return Jan. 15
Latest Manchester United team news
Expected Lineup:
GK André Onana
CB Matthijs de Ligt | CB Harry Maguire | CB Lisandro Martínez
LM Diogo Dalot | CM Bruno Fernandes | CM Kobbie Mainoo | RM Noussair Mazraoui
AM Alejandro Garnacho | AM Amad Diallo
ST Rasmus Højlund
Injury/suspension updates:
Matthijs de Ligt, D, illness, DOUBT
Victor Lindelöf, D, concussion, OUT, estimated return Dec. 30
Mason Mount, F/M, strain, OUT, estimated return Jan. 5
Luke Shaw, D, calf, OUT, estimated return Jan. 5
Liverpool v Leicester City
Anfield
Thursday, 8 p.m. GMT / 3 p.m. ET
Latest Liverpool team news
Expected Lineup:
GK Alisson Becker
LB Andrew Robertson | CB Joe Gomez | CB Virgil van Dijk | RB Trent Alexander-Arnold
CM Ryan Gravenberch | CM Curtis Jones | CM Alexis Mac Allister
FWL Cody Gakpo | ST Diogo Jota | FWR Mohamed Salah
Injury/suspension updates:
Conor Bradley, D, hamstring, OUT, estimated return Dec. 29
Ibrahima Konaté, D, foot, OUT, estimated return Dec. 29
Latest Leicester City team news
Expected Lineup:
GK Danny Ward
LB Victor Kristiansen | CB Conor Coady | CB Wout Faes | RB James Justin
DM Boubakary Soumaré | DM Harry Winks
LW Bobby De Cordova-Reid | AM Facundo Buonanotte | RW Kasey McAteer
ST Patson Daka
Injury/suspension updates:
Odsonne Édouard, F, undisclosed, OUT, estimated return Jan. 4
Fatawu Issahaku, F, knee, OUT, estimated return Aug. 25
Mads Hermansen, G, groin, DOUBT
Wilfred Ndidi, M, hamstring, OUT, estimated return Jan. 4
Ricardo Pereira, D, hamstring, OUT, estimated return Mar. 15
Jamie Vardy, F, undisclosed, DOUBT
Brighton & Hove Albion v Brentford
American Express Stadium
Friday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Pervis Estupiñán | CB Lewis Dunk | CB Jan Paul van Hecke | RB Tariq Lamptey
DM Yasin Ayari | DM Carlos Baleba
LW Kaoru Mitoma | AM João Pedro | RW Yankuba Minteh
ST Evan Ferguson
Injury/suspension updates:
Jack Hinshelwood, M/D, knee, OUT, estimated return Jan. 4
Ferdi Kadioglu, M/D, toe, OUT, estimated return Jan. 4
Solly March, F/M, knee, DOUBT
James Milner, M/D, hamstring, OUT, estimated return Jan. 11
Adam Webster, D, hamstring, DOUBT
Danny Welbeck, F, ankle, OUT, estimated return Jan. 4
Mats Wieffer, M, undisclosed, DOUBT
Latest Brentford team news
Expected Lineup:
GK Mark Flekken
LB Keane Lewis-Potter | CB Nathan Collins | CB Ben Mee | RB Mads Roerslev
CM Mikkel Damsgaard | CM Vitaly Janelt | CM Christian Nørgaard
FWL Kevin Schade | ST Yoane Wissa | FWR Bryan Mbeumo
Injury/suspension updates:
Kristoffer Ajer, D, ankle, OUT, estimated return Feb. 2
Josh Dasilva, M, knee, OUT, estimated return Jan. 14
Rico Henry, M/D, knee, OUT, estimated return Jan. 11
Aaron Hickey, M/D, hamstring, OUT, estimated return May. 18
Mathias Jensen, M, hamstring, OUT, estimated return Jan. 1
Igor Thiago, F, infection, OUT, estimated return Jan. 4
Gustavo Nunes, F/M, back, OUT, estimated return Jan. 11
Ethan Pinnock, D, hamstring, OUT, estimated return Jan. 18
Mads Roerslev, D, undisclosed, DOUBT
Sepp van den Berg, D, groin, OUT, estimated return Jan. 1
Arsenal v Ipswich Town
Emirates Stadium
Friday, 8.15 p.m. GMT / 3.15 p.m. ET
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Riccardo Calafiori | CB Gabriel Magalhães | CB William Saliba | RB Jurriën Timber
CM Martin Ødegaard | CM Mikel Merino | CM Declan Rice
FWL Leandro Trossard | ST Kai Havertz | FWR Gabriel Martinelli
Injury/suspension updates:
Bukayo Saka, F/M, hamstring, OUT, estimated return Jan. 22
Raheem Sterling, F/M, knee, OUT, estimated return Jan. 15
Takehiro Tomiyasu, D, knee, OUT, estimated return Jan. 12
Ben White, D, knee, OUT, estimated return Jan. 15
Oleksandr Zinchenko, D, undisclosed, OUT, estimated return Jan. 1
Latest Ipswich Town team news
Expected Lineup:
GK Aro Muric
LB Leif Davis | CB Jacob Greaves | CB Dara O'Shea | RB Ben Johnson
DM Jens Cajuste | DM Kalvin Phillips
LW Sammie Szmodics | AM Omari Hutchinson | RW Wes Burns
ST Liam Delap
Injury/suspension updates:
George Hirst, F, knee, OUT, estimated return Jan. 19
Sam Morsy, M, suspension, due back Dec. 30
Chiedozie Ogbene, F/M, achilles, OUT, estimated return May. 3
Axel Tuanzebe, D, hamstring, OUT, estimated return Feb. 1