Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the predicted XIs for all 20 clubs.
Positions: Goalkeeper (GK or G), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All predicted XIs and injury news powered by Rotowire.)
Leicester City v Nottingham Forest
King Power Stadium
Friday, 3 p.m. ET / 8 p.m. UK
Latest Leicester City team news
Expected Lineup:
GK Mads Hermansen
LB Victor Kristiansen | CB Wout Faes | CB Caleb Okoli | RB James Justin
DM Wilfred Ndidi | DM Harry Winks
LW Stephy Mavididi | AM Bilal El Khannouss | RW Facundo Buonanotte
ST Jamie Vardy
Injury/suspension updates:
Hamza Choudhury, M, shoulder, OUT, estimated return Nov. 23
Patson Daka, F, ankle, OUT, estimated return Nov. 2
Jakub Stolarczyk, G, ankle, OUT, estimated return Nov. 23
Jannik Vestergaard, D, undisclosed, OUT, estimated return Nov. 10
Latest Nottingham Forest team news
Expected Lineup:
GK Matz Sels
LB Álex Moreno | CB Murillo | CB Nikola Milenkovic | RB Ola Aina
DM James Ward-Prowse | DM Ryan Yates
LW Anthony Elanga | AM Elliot Anderson | RW Callum Hudson-Odoi
ST Chris Wood
Injury/suspension updates:
Morgan Gibbs-White, F/M, ankle, DOUBT
Danilo Oliveira, M, ankle, OUT, estimated return Dec. 21
Ibrahim Sangaré, M, thigh, OUT, estimated return Nov. 23
Aston Villa v AFC Bournemouth
Villa Park
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Aston Villa team news
Expected Lineup:
GK Emiliano Martínez
LB Lucas Digne | CB Ezri Konsa | CB Pau Torres | RB Matty Cash
DM Amadou Onana | DM Youri Tielemans
LW Jacob Ramsey | AM Morgan Rogers | RW Leon Bailey
ST Ollie Watkins
Injury/suspension updates:
Robin Olsen, G, undisclosed, OUT, estimated return Nov. 9
Jaden Philogene, F/M, suspension, due back Nov. 3
Latest AFC Bournemouth team news
Expected Lineup:
GK Kepa Arrizabalaga
LB Milos Kerkez | CB Marcos Senesi | CB Illia Zabarnyi | RB Adam Smith
DM Ryan Christie | DM Lewis Cook
LW Marcus Tavernier | AM Justin Kluivert | RW Antoine Semenyo
ST Evanilson
Injury/suspension updates:
Alex Scott, M, knee, OUT, estimated return Dec. 21
Luis Fernando Sinisterra Lucumi, F/M, undisclosed, OUT, estimated return Nov. 2
Brentford v Ipswich Town
Gtech Community Stadium
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Brentford team news
Expected Lineup:
GK Mark Flekken
LB Kristoffer Ajer | CB Nathan Collins | CB Ethan Pinnock | RB Sepp van den Berg
DM Vitaly Janelt | DM Christian Nørgaard
LW Yoane Wissa | AM Mikkel Damsgaard | RW Bryan Mbeumo
ST Kevin Schade
Injury/suspension updates:
Josh Dasilva, M, knee, OUT, estimated return Nov. 23
Rico Henry, M/D, knee, OUT, estimated return Nov. 4
Aaron Hickey, M/D, hamstring, OUT, estimated return May. 18
Mathias Jensen, M, calf, DOUBT
Igor Thiago, F, knee, OUT, estimated return Nov. 30
Gustavo Nunes, F/M, back, OUT, estimated return Nov. 23
Latest Ipswich Town team news
Expected Lineup:
GK Aro Muric
LB Leif Davis | CB Cameron Burgess | CB Dara O'Shea | RB Harrison Clarke
DM Sam Morsy | DM Kalvin Phillips
LW Jack Clarke | AM Conor Chaplin | RW Omari Hutchinson
ST Liam Delap
Injury/suspension updates:
Ali Ibrahim Al-Hamadi, F, groin, DOUBT
Jens Cajuste, M, knee, DOUBT
Jacob Greaves, D, undisclosed, OUT, estimated return Nov. 2
Ben Johnson, D, thigh, OUT, estimated return Nov. 2
Massimo Luongo, M, ankle, OUT, estimated return Nov. 24
Cieran Slicker, G, undisclosed, OUT, estimated return Nov. 2
Axel Tuanzebe, D, hand, OUT, estimated return Nov. 24
Brighton & Hove Albion v Wolverhampton Wanderers
American Express Stadium
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Ferdi Kadioglu | CB Lewis Dunk | CB Jan Paul van Hecke | RB Joël Veltman
CM Carlos Baleba | CM Mats Wieffer | CM Jack Hinshelwood
FWL Kaoru Mitoma | ST Evan Ferguson | FWR Georginio Rutter
Injury/suspension updates:
Simon Adingra, F/M, undisclosed, DOUBT
João Pedro, F/M, ankle, OUT, estimated return Nov. 2
Solly March, F/M, knee, DOUBT
James Milner, M/D, hamstring, DOUBT
Yankuba Minteh, F, undisclosed, DOUBT
Matt O'Riley, M, ankle, OUT, estimated return Dec. 16
Adam Webster, D, hamstring, OUT, estimated return Nov. 23
Danny Welbeck, F, back, DOUBT
Latest Wolverhampton Wanderers team news
Expected Lineup:
GK Sam Johnstone
CB Santiago Bueno | CB Craig Dawson | CB Toti Gomes
LM Rayan Aït-Nouri | CM Tommy Doyle | CM João Gomes | CM Mario Lemina | RM Nélson Semedo
ST Jørgen Strand Larsen | ST Matheus Cunha
Injury/suspension updates:
Enso Gonzalez, F/M, knee, OUT, estimated return May. 3
Hwang Hee-Chan, F, ankle, OUT, estimated return Nov. 9
Sam Johnstone, G, groin, DOUBT
Sasa Kalajdzic, F, knee, OUT, estimated return Jan. 15
Bastien Meupiyou, M/D, undisclosed, OUT, estimated return Nov. 23
Yerson Mosquera, D, knee, OUT, estimated return Aug. 15
Boubacar Traoré, M, knee, OUT, estimated return Jan. 15
Manchester City v Southampton
Etihad Stadium
Saturday, 10 a.m. ET / 3 p.m. UK
Latest Manchester City team news
Expected Lineup:
GK Ederson
LB Josko Gvardiol | CB Manuel Akanji | CB Rúben Dias | RB Rico Lewis
DM Mateo Kovacic
LM Phil Foden | CM Bernardo Silva | CM Ilkay Gündogan | RM Savinho
ST Erling Haaland
Injury/suspension updates:
Oscar Bobb, F/M, leg, OUT, estimated return Nov. 30
Kevin De Bruyne, F/M, groin, OUT, estimated return Nov. 2
Jérémy Doku, F/M, undisclosed, OUT, estimated return Nov. 5
Jack Grealish, F/M, undisclosed, OUT, estimated return Nov. 2
Rodri, M, knee, OUT, estimated return Jul. 1
Kyle Walker, D, knee, OUT, estimated return Nov. 2
Latest Southampton team news
Expected Lineup:
GK Aaron Ramsdale
LB Kyle Walker-Peters | CB Jan Bednarek | CB Taylor Harwood-Bellis | CB Jack Stephens | RB Yukinari Sugawara
LM Mateus Fernandes | CM Joe Aribo | CM Flynn Downes | RM Tyler Dibling
ST Cameron Archer
Injury/suspension updates:
Gavin Bazunu, G, achilles, OUT, estimated return Jan. 11
Ryan Fraser, F/M, suspension, due back Nov. 2
William Smallbone, M, hamstring, OUT, estimated return Nov. 9
Ross Stewart, F, calf, OUT, estimated return Nov. 9
Yukinari Sugawara, M/D, undisclosed, DOUBT
Everton v Fulham
Goodison Park
Saturday, 12:30 p.m. ET / 5:30 p.m. UK
Latest Everton team news
Expected Lineup:
GK Jordan Pickford
LB Vitaliy Mykolenko | CB Jarrad Branthwaite | CB James Tarkowski | RB Ashley Young
DM Abdoulaye Doucouré | DM Idrissa Gueye
LW Iliman Ndiaye | AM Dwight McNeil | RW Jack Harrison
ST Dominic Calvert-Lewin
Injury/suspension updates:
Jarrad Branthwaite, D, groin, DOUBT
Armando Broja, F, ankle, OUT, estimated return Nov. 9
James Garner, M, back, OUT, estimated return Nov. 2
Tim Iroegbunam, M, foot, OUT, estimated return Nov. 23
Jesper Lindstrom, F/M, illness, DOUBT
Youssef Chermiti, F, foot, OUT, estimated return Nov. 23
Latest Fulham team news
Expected Lineup:
GK Bernd Leno
LB Antonee Robinson | CB Calvin Bassey | CB Issa Diop | RB Kenny Tete
DM Sander Berge | DM Andreas Pereira
LW Alex Iwobi | AM Emile Smith Rowe | RW Adama Traoré
ST Raúl Jiménez
Injury/suspension updates:
Joachim Andersen, D, suspension, due back Nov. 4
Timothy Castagne, D, hamstring, OUT, estimated return Nov. 23
Jorge Cuenca, D, ankle, DOUBT
Sasa Lukic, M, shoulder, OUT, estimated return Nov. 23
Carlos Vinícius, F, undisclosed, DOUBT
Chelsea v Newcastle United
Stamford Bridge
Sunday, 10 a.m. ET / 2 p.m. UK
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Malo Gusto | CB Levi Colwill | CB Wesley Fofana | RB Reece James
DM Moisés Caicedo | DM Enzo Fernández
LW Jadon Sancho | AM Cole Palmer | RW Noni Madueke
ST Nicolas Jackson
Injury/suspension updates:
None reported
Latest Newcastle United team news
Expected Lineup:
GK Nick Pope
LB Lewis Hall | CB Dan Burn | CB Fabian Schär | RB Valentino Livramento
CM Joelinton | CM Bruno Guimaraes | CM Sandro Tonali
FWL Harvey Barnes | ST Alexander Isak | FWR Anthony Gordon
Injury/suspension updates:
Sven Botman, D, knee, OUT, estimated return Dec. 4
Jamaal Lascelles, D, knee, OUT, estimated return Jan. 15
Matt Targett, D, not injury related, DOUBT
Kieran Trippier, D, undisclosed, OUT, estimated return Nov. 10
Callum Wilson, F, back, OUT, estimated return Nov. 25
Crystal Palace v Tottenham Hotspur
Selhurst Park
Sunday, 10 a.m. ET / 2 p.m. UK
Latest Crystal Palace team news
Expected Lineup:
GK Dean Henderson
CB Trevoh Chalobah | CB Marc Guéhi | CB Maxence Lacroix
LM Tyrick Mitchell | CM Will Hughes | CM Jefferson Lerma | RM Daniel Muñoz
AM Eberechi Eze | AM Daichi Kamada
ST Eddie Nketiah
Injury/suspension updates:
Cheick Doucoure, M, toe, OUT, estimated return Nov. 2
Matheus França, F/M, groin, DOUBT
Chadi Riad, D, knee, OUT, estimated return Nov. 23
Chris Richards, D, hamstring, OUT, estimated return Nov. 2
Latest Tottenham Hotspur team news
Expected Lineup:
GK Guglielmo Vicario
LB Destiny Udogie | CB Cristian Romero | CB Micky van de Ven | RB Pedro Porro
CM James Maddison | CM Yves Bissouma | CM Pape Matar Sarr
FWL Dejan Kulusevski | ST Dominic Solanke | FWR Brennan Johnson
Injury/suspension updates:
Son Heung-Min, F/M, strain, DOUBT
Djed Spence, M/D, groin, OUT, estimated return Nov. 3
West Ham United v Manchester United
London Stadium
Sunday, 10 a.m. ET / 2 p.m. UK
Latest West Ham United team news
Expected Lineup:
GK Alphonse Areola
LB Emerson | CB Max Kilman | CB Jean-Clair Todibo | RB Aaron Wan-Bissaka
DM Edson Álvarez | DM Guido Rodríguez
LW Carlos Soler | AM Lucas Paquetá | RW Jarrod Bowen
ST Michail Antonio
Injury/suspension updates:
Niclas Füllkrug, F, calf, OUT, estimated return Nov. 2
Mohammed Kudus, F/M, suspension, due back Nov. 25
Latest Manchester United team news
Expected Lineup:
GK André Onana
LB Diogo Dalot | CB Matthijs de Ligt | CB Lisandro Martínez | RB Noussair Mazraoui
DM Christian Eriksen | DM Casemiro
LW Alejandro Garnacho | AM Bruno Fernandes | RW Marcus Rashford
ST Rasmus Højlund
Injury/suspension updates:
Toby Collyer, M, undisclosed, DOUBT
Antony, F, ankle, OUT, estimated return Nov. 3
Jonny Evans, D, undisclosed, DOUBT
Harry Maguire, D, calf, OUT, estimated return Nov. 3
Kobbie Mainoo, M, knee, OUT, estimated return Nov. 3
Tyrell Malacia, D, knee, OUT, estimated return Nov. 10
Mason Mount, F/M, head, OUT, estimated return Nov. 3
Luke Shaw, D, calf, OUT, estimated return Nov. 3
Leny Yoro, D, foot, OUT, estimated return Nov. 24
Arsenal v Liverpool
Emirates Stadium
Sunday, 12:30 p.m. ET / 4:30 p.m. UK
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Oleksandr Zinchenko | CB Gabriel Magalhaes | CB Ben White | RB Thomas Partey
CM Jorginho | CM Mikel Merino | CM Declan Rice
FWL Leandro Trossard | ST Kai Havertz | FWR Raheem Sterling
Injury/suspension updates:
Riccardo Calafiori, D, knee, DOUBT
Martin Ødegaard, F/M, ankle, OUT, estimated return Nov. 6
Bukayo Saka, F/M, hamstring, DOUBT
William Saliba, D, suspension, due back Nov. 2
Kieran Tierney, D, hamstring, OUT, estimated return Nov. 23
Jurriën Timber, D, strain, DOUBT
Latest Liverpool team news
Expected Lineup:
GK Caoimhín Kelleher
LB Andrew Robertson | CB Ibrahima Konaté | CB Virgil van Dijk | RB Trent Alexander-Arnold
DM Ryan Gravenberch | DM Alexis Mac Allister
LW Luis Díaz | AM Dominik Szoboszlai | RW Mohamed Salah
ST Darwin Núñez
Injury/suspension updates:
Alisson Becker, G, hamstring, OUT, estimated return Nov. 24
Conor Bradley, D, undisclosed, OUT, estimated return Nov. 2
Federico Chiesa, F/M, undisclosed, OUT, estimated return Nov. 2
Harvey Elliott, F/M, foot, OUT, estimated return Nov. 2
Diogo Jota, F, upper body, OUT, estimated return Nov. 2