While the injury was given a timetable of 15 days for a return, a setback in his recovery could limit his participation for the Nov. 21 World Cup opener against Wales in Qatar. The USMNT is returning to the World Cup after it did not qualify in 2018.
Other injury concerns include midfielder Luca de la Torre (hamstring) and goalkeeper Matt Turner (groin). Midfielder Tyler Adams had been dealing with an undisclosed injury but returned Saturday as Leeds United earned a 2-1 victory over Liverpool.
McKennie has been a regular presence for Juventus this season, playing in 11 Serie A matches and five Champions League games, scoring three goals across both competitions.
McKennie's absence also mean Juventus prepares to face Paris Saint-Germain in the Champions League on Wednesday without 12 players through injury. Teenage winger Samuel Iling-Junior injured his ankle on Saturday and will be out for around three weeks.
Information from the Associated Press was used in this report.