Yorke has signed a deal to lead the Bulls for the next two ALM seasons in what will be the ex-Trinidad and Tobago international's first senior coaching role.
He'll replace Ante Milicic, who has stepped down after two seasons as the Bulls' foundation coach to move to Croatia for family reasons.
Yorke is no stranger to Australian football having been Sydney FC's marquee player in the inaugural ALM season in 2005-06, as the Sky Blues went on to win the first ALM Grand Final.
"Having played in the inaugural A-League Men's season I have continually followed the competition and am aware of both the footballing and fan demands in Australia," Yorke said.
"I look forward to adding a positive contribution and improve the game at all levels, however of course my primary focus will be with the Bulls, to deliver them success and a style of football that defined me as a player."
Yorke scored 123 goals in the Premier League during his playing career and was part of the United team which claimed the 1999 European Champions League title.
"Dwight's football exposure and achievements speak volumes," Bulls chief executive Sam Krslovic said. "As a young club, the appointment of Dwight is synonymous with our evolution."
After reaching finals in their inaugural season in 2020-21, the Bulls missed out on playoffs this season, finishing seventh on the ladder.