Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Brighton & Hove Albion v Crystal Palace
American Express Stadium
Sunday, 2 p.m. GMT / 9 a.m. ET
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Pervis Estupiñán | CB Lewis Dunk | CB Jan Paul van Hecke | RB Tariq Lamptey
DM Yasin Ayari | DM Carlos Baleba
LW Kaoru Mitoma | AM João Pedro | RW Georginio Rutter
ST Danny Welbeck
Injury/suspension updates:
Jack Hinshelwood, M/D, knee, DOUBT
Ferdi Kadioglu, M/D, toe, DOUBT
Solly March, F/M, knee, DOUBT
James Milner, M/D, hamstring, DOUBT
Joël Veltman, D, undisclosed, DOUBT
Adam Webster, D, hamstring, DOUBT
Latest Crystal Palace team news
Expected Lineup:
GK Dean Henderson
CB Trevoh Chalobah | CB Marc Guéhi | CB Maxence Lacroix
LM Tyrick Mitchell | CM Will Hughes | CM Jefferson Lerma | RM Daniel Muñoz
AM Eberechi Eze | AM Ismaïla Sarr
ST Jean-Philippe Mateta
Injury/suspension updates:
Matheus França, F/M, groin, DOUBT
Chadi Riad, D, knee, OUT, estimated return Dec. 21
Adam Wharton, M, groin, DOUBT
Manchester City v Manchester United
Etihad Stadium
Sunday, 4:30 p.m. GMT / 11:30 a.m. ET
Latest Manchester City team news
Expected Lineup:
GK Stefan Ortega
LB Josko Gvardiol | CB Rúben Dias | CB Jahmai Simpson-Pusey | RB Kyle Walker
DM Bernardo Silva | DM Ilkay Gündogan
LW Matheus Nunes | AM Phil Foden | RW Savinho
ST Erling Haaland
Injury/suspension updates:
Manuel Akanji, D, undisclosed, OUT, estimated return Dec. 21
Nathan Aké, D, hamstring, OUT, estimated return Dec. 26
Oscar Bobb, F/M, leg, OUT, estimated return Jan. 14
Rodri, M, knee, OUT, estimated return Jul. 1
Rico Lewis, M/D, suspension, due back Dec. 21
John Stones, D, foot, OUT, estimated return Dec. 21
Latest Manchester United team news
Expected Lineup:
GK André Onana
CB Matthijs de Ligt | CB Lisandro Martínez | CB Noussair Mazraoui
LM Diogo Dalot | CM Kobbie Mainoo | CM Manuel Ugarte | RM Amad Diallo
AM Alejandro Garnacho | AM Bruno Fernandes
ST Rasmus Højlund
Injury/suspension updates:
Jonny Evans, D, undisclosed, DOUBT
Luke Shaw, D, calf, OUT, estimated return Jan. 5
Chelsea v Brentford
Stamford Bridge
Sunday, 7 p.m. GMT / 2 p.m. ET
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Marc Cucurella | CB Benoît Badiashile | CB Levi Colwill | RB Malo Gusto
DM Moisés Caicedo | DM Enzo Fernández
LW Jadon Sancho | AM Cole Palmer | RW Noni Madueke
ST Nicolas Jackson
Injury/suspension updates:
Wesley Fofana, D, hamstring, OUT, estimated return Dec. 22
Reece James, D, hamstring, OUT, estimated return Jan. 4
Mykhailo Mudryk, F/M, illness, DOUBT
Pedro Neto, F/M, suspension, due back Dec. 22
Latest Brentford team news
Expected Lineup:
GK Mark Flekken
LB Keane Lewis-Potter | CB Nathan Collins | CB Ethan Pinnock | RB Sepp van den Berg
DM Christian Nørgaard | DM Yehor Yarmolyuk
LW Yoane Wissa | AM Mikkel Damsgaard | RW Bryan Mbeumo
ST Igor Thiago
Injury/suspension updates:
Josh Dasilva, M, knee, OUT, estimated return Jan. 14
Rico Henry, M/D, knee, DOUBT
Aaron Hickey, M/D, hamstring, OUT, estimated return May. 18
Vitaly Janelt, M, undisclosed, DOUBT
Mathias Jensen, M, hamstring, DOUBT
Gustavo Nunes, F/M, back, DOUBT
Southampton v Tottenham Hotspur
St. Mary's Stadium
Sunday, 7 p.m. GMT / 2 p.m. ET
Latest Southampton team news
Expected Lineup:
GK Joe Lumley
LB Ryan Manning | CB Jan Bednarek | CB Taylor Harwood-Bellis | RB Kyle Walker-Peters
LM Mateus Fernandes | CM Joe Aribo | CM Flynn Downes | RM Tyler Dibling
ST Cameron Archer | ST Adam Armstrong
Injury/suspension updates:
Gavin Bazunu, G, achilles, OUT, estimated return Jan. 11
Jan Bednarek, D, knee, DOUBT
Adam Lallana, M, hamstring, DOUBT
Paul Onuachu, F, undisclosed, DOUBT
Aaron Ramsdale, G, finger, OUT, estimated return Dec. 18
William Smallbone, M, hamstring, OUT, estimated return Dec. 29
Jack Stephens, D, suspension, due back Dec. 26
Ross Stewart, F, calf, OUT, estimated return Dec. 29
Latest Tottenham Hotspur team news
Expected Lineup:
GK Fraser Forster
LB Destiny Udogie | CB Radu Dragusin | CB Archie Gray | RB Pedro Porro
CM Dejan Kulusevski | CM James Maddison | CM Pape Matar Sarr
FWL Son Heung-Min | ST Dominic Solanke | FWR Brennan Johnson
Injury/suspension updates:
Rodrigo Bentancur, M, suspension, due back Dec. 26
Yves Bissouma, M, suspension, due back Dec. 22
Ben Davies, D, hamstring, OUT, estimated return Dec. 29
Richarlison, F, hamstring, OUT, estimated return Dec. 15
Mikey Moore, F/M, illness, OUT, estimated return Dec. 29
Wilson Odobert, F/M, hamstring, OUT, estimated return Feb. 15
Cristian Romero, D, quadriceps, OUT, estimated return Jan. 12
Micky van de Ven, D, hamstring, OUT, estimated return Jan. 12
Guglielmo Vicario, G, ankle, OUT, estimated return Feb. 25
AFC Bournemouth v West Ham United
Vitality Stadium
Monday, 8 p.m. GMT / 3 p.m. ET
Latest AFC Bournemouth team news
Expected Lineup:
GK Kepa Arrizabalaga
LB Milos Kerkez | CB Dean Huijsen | CB Illia Zabarnyi | RB Adam Smith
DM Ryan Christie | DM Lewis Cook
LW Dango Ouattara | AM Justin Kluivert | RW Antoine Semenyo
ST Evanilson
Injury/suspension updates:
Julián Araujo, D, hamstring, OUT, estimated return Feb. 25
Alex Scott, M, knee, OUT, estimated return Dec. 21
Marcos Senesi, D, quadriceps, OUT, estimated return Mar. 15
Luis Sinisterra, F/M, hamstring, DOUBT
Marcus Tavernier, F/M, hamstring, OUT, estimated return Jan. 25
Latest West Ham United team news
Expected Lineup:
GK Lukasz Fabianski
LB Aaron Wan-Bissaka | CB Max Kilman | CB Konstantinos Mavropanos | RB Vladimír Coufal
DM Edson Álvarez | DM Tomás Soucek
LW Crysencio Summerville | AM Carlos Soler | RW Mohammed Kudus
ST Jarrod Bowen
Injury/suspension updates:
Michail Antonio, F, leg, OUT, estimated return Dec. 1