Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Arsenal v Everton
Emirates Stadium
Saturday, 3 p.m. GMT / 10 a.m. ET
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Jurriën Timber | CB Gabriel Magalhães | CB William Saliba | RB Thomas Partey
CM Martin Ødegaard | CM Jorginho | CM Declan Rice
FWL Leandro Trossard | ST Kai Havertz | FWR Bukayo Saka
Injury/suspension updates:
Riccardo Calafiori, D, undisclosed, DOUBT
Gabriel Magalhães, D, undisclosed, DOUBT
Takehiro Tomiyasu, D, knee, OUT, estimated return Dec. 21
Ben White, D, knee, OUT, estimated return Jan. 15
Oleksandr Zinchenko, D, undisclosed, DOUBT
Latest Everton team news
Expected Lineup:
GK Jordan Pickford
LB Vitaliy Mykolenko | CB Jarrad Branthwaite | CB James Tarkowski | RB Ashley Young
DM Idrissa Gueye | DM Orel Mangala
LW Dwight McNeil | AM Abdoulaye Doucouré | RW Iliman Ndiaye
ST Dominic Calvert-Lewin
Injury/suspension updates:
James Garner, M, back, OUT, estimated return Jan. 9
Tim Iroegbunam, M, foot, OUT, estimated return Jan. 9
Michael Keane, D, knee, DOUBT
Youssef Chermiti, F, foot, OUT, estimated return Dec. 26
Liverpool v Fulham
Anfield
Saturday, 3 p.m. GMT / 10 a.m. ET
Latest Liverpool team news
Expected Lineup:
GK Alisson Becker
LB Andrew Robertson | CB Joe Gomez | CB Virgil van Dijk | RB Trent Alexander-Arnold
DM Ryan Gravenberch | DM Curtis Jones
LW Cody Gakpo | AM Dominik Szoboszlai | RW Mohamed Salah
ST Luis Díaz
Injury/suspension updates:
Conor Bradley, D, hamstring, OUT, estimated return Dec. 29
Federico Chiesa, F/M, undisclosed, DOUBT
Diogo Jota, F, upper body, DOUBT
Ibrahima Konaté, D, foot, OUT, estimated return Dec. 29
Kostas Tsimikas, D, ankle, DOUBT
Latest Fulham team news
Expected Lineup:
GK Bernd Leno
LB Antonee Robinson | CB Jorge Cuenca | CB Issa Diop | RB Kenny Tete
DM Sander Berge | DM Sasa Lukic
LW Alex Iwobi | AM Emile Smith Rowe | RW Harry Wilson
ST Raúl Jiménez
Injury/suspension updates:
Joachim Andersen, D, calf, OUT, estimated return Dec. 22
Calvin Bassey, D, suspension, due back Dec. 22
Tom Cairney, M, suspension, due back Dec. 22
Reiss Nelson, F/M, hamstring, OUT, estimated return Feb. 20
Harrison Reed, M, knee, OUT, estimated return Dec. 29
Newcastle United v Leicester City
St. James' Park
Saturday, 3 p.m. GMT / 10 a.m. ET
Latest Newcastle United team news
Expected Lineup:
GK Nick Pope
LB Lewis Hall | CB Dan Burn | CB Fabian Schär | RB Valentino Livramento
CM Joelinton | CM Bruno Guimaraes | CM Sandro Tonali
FWL Anthony Gordon | ST Alexander Isak | FWR Jacob Murphy
Injury/suspension updates:
Sven Botman, D, knee, OUT, estimated return Dec. 26
Emil Krafth, D, collarbone, OUT, estimated return Jan. 4
Jamaal Lascelles, D, knee, OUT, estimated return Jan. 15
Nick Pope, G, undisclosed, DOUBT
Joe Willock, M, hamstring, DOUBT
Callum Wilson, F, hamstring, OUT, estimated return Feb. 1
Latest Leicester City team news
Expected Lineup:
GK Mads Hermansen
LB Victor Kristiansen | CB Conor Coady | CB Jannik Vestergaard | RB James Justin
DM Hamza Choudhury | DM Oliver Skipp
LW Bilal El Khannouss | AM Facundo Buonanotte | RW Kasey McAteer
ST Jamie Vardy
Injury/suspension updates:
Odsonne Édouard, F, undisclosed, OUT, estimated return Dec. 26
Fatawu Issahaku, F, knee, OUT, estimated return Aug. 25
Wilfred Ndidi, M, hamstring, OUT, estimated return Jan. 4
Ricardo Pereira, D, hamstring, OUT, estimated return Mar. 15
Boubakary Soumaré, M, suspension, due back Dec. 22
Jakub Stolarczyk, G, ankle, OUT, estimated return Dec. 22
Harry Winks, M, groin, DOUBT
Wolverhampton Wanderers v Ipswich Town
Molineux Stadium
Saturday, 3 p.m. GMT / 10 a.m. ET
Latest Wolverhampton Wanderers team news
Expected Lineup:
GK Sam Johnstone
CB Santiago Bueno | CB Toti Gomes | CB Nélson Semedo
LM Rayan Aït-Nouri | CM Mario Lemina | CM Andre | RM Matt Doherty
AM Goncalo Guedes | AM Matheus Cunha
ST Jørgen Strand Larsen
Injury/suspension updates:
João Gomes, M, suspension, due back Dec. 22
Enso Gonzalez, F/M, knee, OUT, estimated return May. 3
Sasa Kalajdzic, F, knee, OUT, estimated return Jan. 15
Yerson Mosquera, D, knee, OUT, estimated return Aug. 15
José Sá, G, shoulder, OUT, estimated return Dec. 22
Pablo Sarabia, F/M, undisclosed, OUT, estimated return Dec. 22
Boubacar Traoré, M, knee, OUT, estimated return Jan. 15
Latest Ipswich Town team news
Expected Lineup:
GK Aro Muric
LB Leif Davis | CB Jacob Greaves | CB Dara O'Shea | RB Ben Johnson
DM Jens Cajuste | DM Sam Morsy
LW Jack Clarke | AM Omari Hutchinson | RW Wes Burns
ST Liam Delap
Injury/suspension updates:
George Hirst, F, knee, OUT, estimated return Dec. 27
Chiedozie Ogbene, F/M, achilles, OUT, estimated return May. 3
Kalvin Phillips, M, ankle, DOUBT
Axel Tuanzebe, D, hamstring, OUT, estimated return Feb. 1
Nottingham Forest v Aston Villa
The City Ground
Saturday, 5:30 p.m. GMT / 12:30 p.m. ET
Latest Nottingham Forest team news
Expected Lineup:
GK Matz Sels
LB Neco Williams | CB Murillo | CB Nikola Milenkovic | RB Ola Aina
DM Elliot Anderson | DM Ryan Yates
LW Callum Hudson-Odoi | AM Morgan Gibbs-White | RW Joao Pedro
ST Chris Wood
Injury/suspension updates:
Álex Moreno, D, not injury related, OUT, estimated return Dec. 21
Danilo Oliveira, M, ankle, OUT, estimated return Dec. 21
Ibrahim Sangaré, M, thigh, OUT, estimated return Jan. 25
Latest Aston Villa team news
Expected Lineup:
GK Emiliano Martínez
LB Ian Maatsen | CB Diego Carlos | CB Pau Torres | RB Ezri Konsa
DM Youri Tielemans | DM Boubacar Kamara
LW Morgan Rogers | AM John McGinn | RW Matty Cash
ST Jhon Jader Duran
Injury/suspension updates:
Leon Bailey, F/M, hamstring, DOUBT
Jacob Ramsey, M, hamstring, OUT, estimated return Dec. 26
Ollie Watkins, F, undisclosed, DOUBT
Brighton & Hove Albion v Crystal Palace
American Express Stadium
Sunday, 2 p.m. GMT / 9 a.m. ET
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Pervis Estupiñán | CB Lewis Dunk | CB Jan Paul van Hecke | RB Tariq Lamptey
DM Yasin Ayari | DM Carlos Baleba
LW Kaoru Mitoma | AM João Pedro | RW Georginio Rutter
ST Danny Welbeck
Injury/suspension updates:
Jack Hinshelwood, M/D, knee, DOUBT
Ferdi Kadioglu, M/D, toe, DOUBT
Solly March, F/M, knee, DOUBT
James Milner, M/D, hamstring, DOUBT
Joël Veltman, D, undisclosed, DOUBT
Adam Webster, D, hamstring, DOUBT
Latest Crystal Palace team news
Expected Lineup:
GK Dean Henderson
CB Trevoh Chalobah | CB Marc Guéhi | CB Maxence Lacroix
LM Tyrick Mitchell | CM Will Hughes | CM Jefferson Lerma | RM Daniel Muñoz
AM Eberechi Eze | AM Ismaïla Sarr
ST Jean-Philippe Mateta
Injury/suspension updates:
Matheus França, F/M, groin, DOUBT
Chadi Riad, D, knee, OUT, estimated return Dec. 21
Adam Wharton, M, groin, DOUBT
Manchester City v Manchester United
Etihad Stadium
Sunday, 4:30 p.m. GMT / 11:30 a.m. ET
Latest Manchester City team news
Expected Lineup:
GK Stefan Ortega
LB Josko Gvardiol | CB Rúben Dias | CB Jahmai Simpson-Pusey | RB Kyle Walker
DM Bernardo Silva | DM Ilkay Gündogan
LW Matheus Nunes | AM Phil Foden | RW Savinho
ST Erling Haaland
Injury/suspension updates:
Manuel Akanji, D, undisclosed, OUT, estimated return Dec. 21
Nathan Aké, D, hamstring, OUT, estimated return Dec. 26
Oscar Bobb, F/M, leg, OUT, estimated return Jan. 14
Rodri, M, knee, OUT, estimated return Jul. 1
Rico Lewis, M/D, suspension, due back Dec. 21
John Stones, D, foot, OUT, estimated return Dec. 21
Latest Manchester United team news
Expected Lineup:
GK André Onana
CB Matthijs de Ligt | CB Lisandro Martínez | CB Noussair Mazraoui
LM Diogo Dalot | CM Kobbie Mainoo | CM Manuel Ugarte | RM Amad Diallo
AM Alejandro Garnacho | AM Bruno Fernandes
ST Rasmus Højlund
Injury/suspension updates:
Jonny Evans, D, undisclosed, DOUBT
Luke Shaw, D, calf, OUT, estimated return Jan. 5
Chelsea v Brentford
Stamford Bridge
Sunday, 7 p.m. GMT / 2 p.m. ET
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Marc Cucurella | CB Benoît Badiashile | CB Levi Colwill | RB Malo Gusto
DM Moisés Caicedo | DM Enzo Fernández
LW Jadon Sancho | AM Cole Palmer | RW Noni Madueke
ST Nicolas Jackson
Injury/suspension updates:
Wesley Fofana, D, hamstring, OUT, estimated return Dec. 22
Reece James, D, hamstring, OUT, estimated return Jan. 4
Mykhailo Mudryk, F/M, illness, DOUBT
Pedro Neto, F/M, suspension, due back Dec. 22
Latest Brentford team news
Expected Lineup:
GK Mark Flekken
LB Keane Lewis-Potter | CB Nathan Collins | CB Ethan Pinnock | RB Sepp van den Berg
DM Christian Nørgaard | DM Yehor Yarmolyuk
LW Yoane Wissa | AM Mikkel Damsgaard | RW Bryan Mbeumo
ST Igor Thiago
Injury/suspension updates:
Josh Dasilva, M, knee, OUT, estimated return Jan. 14
Rico Henry, M/D, knee, DOUBT
Aaron Hickey, M/D, hamstring, OUT, estimated return May. 18
Vitaly Janelt, M, undisclosed, DOUBT
Mathias Jensen, M, hamstring, DOUBT
Gustavo Nunes, F/M, back, DOUBT
Southampton v Tottenham Hotspur
St. Mary's Stadium
Sunday, 7 p.m. GMT / 2 p.m. ET
Latest Southampton team news
Expected Lineup:
GK Joe Lumley
LB Ryan Manning | CB Jan Bednarek | CB Taylor Harwood-Bellis | RB Kyle Walker-Peters
LM Mateus Fernandes | CM Joe Aribo | CM Flynn Downes | RM Tyler Dibling
ST Cameron Archer | ST Adam Armstrong
Injury/suspension updates:
Gavin Bazunu, G, achilles, OUT, estimated return Jan. 11
Jan Bednarek, D, knee, DOUBT
Adam Lallana, M, hamstring, DOUBT
Paul Onuachu, F, undisclosed, DOUBT
Aaron Ramsdale, G, finger, OUT, estimated return Dec. 18
William Smallbone, M, hamstring, OUT, estimated return Dec. 29
Jack Stephens, D, suspension, due back Dec. 26
Ross Stewart, F, calf, OUT, estimated return Dec. 29
Latest Tottenham Hotspur team news
Expected Lineup:
GK Fraser Forster
LB Destiny Udogie | CB Radu Dragusin | CB Archie Gray | RB Pedro Porro
CM Dejan Kulusevski | CM James Maddison | CM Pape Matar Sarr
FWL Son Heung-Min | ST Dominic Solanke | FWR Brennan Johnson
Injury/suspension updates:
Rodrigo Bentancur, M, suspension, due back Dec. 26
Yves Bissouma, M, suspension, due back Dec. 22
Ben Davies, D, hamstring, OUT, estimated return Dec. 29
Richarlison, F, hamstring, OUT, estimated return Dec. 15
Mikey Moore, F/M, illness, OUT, estimated return Dec. 29
Wilson Odobert, F/M, hamstring, OUT, estimated return Feb. 15
Cristian Romero, D, quadriceps, OUT, estimated return Jan. 12
Micky van de Ven, D, hamstring, OUT, estimated return Jan. 12
Guglielmo Vicario, G, ankle, OUT, estimated return Feb. 25
AFC Bournemouth v West Ham United
Vitality Stadium
Monday, 8 p.m. GMT / 3 p.m. ET
Latest AFC Bournemouth team news
Expected Lineup:
GK Kepa Arrizabalaga
LB Milos Kerkez | CB Dean Huijsen | CB Illia Zabarnyi | RB Adam Smith
DM Ryan Christie | DM Lewis Cook
LW Dango Ouattara | AM Justin Kluivert | RW Antoine Semenyo
ST Evanilson
Injury/suspension updates:
Julián Araujo, D, hamstring, OUT, estimated return Feb. 25
Alex Scott, M, knee, OUT, estimated return Dec. 21
Marcos Senesi, D, quadriceps, OUT, estimated return Mar. 15
Luis Sinisterra, F/M, hamstring, DOUBT
Marcus Tavernier, F/M, hamstring, OUT, estimated return Jan. 25
Latest West Ham United team news
Expected Lineup:
GK Lukasz Fabianski
LB Aaron Wan-Bissaka | CB Max Kilman | CB Konstantinos Mavropanos | RB Vladimír Coufal
DM Edson Álvarez | DM Tomás Soucek
LW Crysencio Summerville | AM Carlos Soler | RW Mohammed Kudus
ST Jarrod Bowen
Injury/suspension updates:
Michail Antonio, F, leg, OUT, estimated return Dec. 1