It's crunch time for this year's Copa Libertadores, with the governments of Argentina and Uruguay to decide on a proposal from CONMEBOL on Tuesday.
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Uruguay were the first-ever winners of the World Cup, but only in the last decade have they returned to the top table of international football.
It's been a decade since South Africa's Bafana Bafana kicked off the 2010 World Cup, the first and only on the continent. Where are they now?
Italy defender Giorgio Chiellini admires Uruguay forward Luis Suarez for biting him during a heated match at the 2014 World Cup, he said.
Barcelona star duo Lionel Messi and Luis Suarez made the move to Europe when they were teenagers, a sign of an evergrowing trend.
FIFA is supporting CONMEBOL's request to suspend World Cup qualifiers scheduled for the end of March due to fears over the coronavirus.
Argentina and Brazil will be representing South America at the Tokyo Olympics, but it could have been so different for two-time champions Uruguay.
LAFC has bolstered its midfield by signing Montevideo Wanderers and Uruguay youth international Francisco Ginella, sources have told ESPN FC.
Australia will face Lionel Messi and Argentina at next year's Copa America after being drawn in Group A for the South American championship.
Edinson Cavani has said his spat with Lionel Messi during Monday's 2-2 international friendly which was caught on camera is "part of football."
Argentina's Lionel Messi scored an added-time penalty to salvage a 2-2 draw vs. Uruguay as they twice came from behind in an entertaining friendly.
Sixty-five years ago, Hungary vs. Uruguay was the greatest football match ever seen. Now,things couldn't be more different for these old rivals.
Jordan Morris scored in the 79th minute to give the United States a 1-1 draw with Uruguay.
It won't get any easier for the U.S. on Tuesday -- the Americans face a Uruguay team that has been masterfully built by Oscar Washington Tabarez.
Lionel Messi and Luis Suarez were back in Barcelona on Friday and the duo will travel to the U.S. on Aug. 5 for matches against Napoli.
The U.S. men's soccer team will play Uruguay in an exhibition at Busch Stadium in St. Louis on Sept. 10.
The Copa America gave plenty of clues for the 2022 World Cup hopes of winners Brazil, Lionel Messi's Argentina and South America's other nations.
Peru were more than happy to sit back and defend against Uruguay, which revealed the attacking issues that Luis Suarez and Co. are facing.
Luis Suarez missed Uruguay's first penalty in a shootout loss as Peru clinched a spot into the Copa America semifinals.
We are down to the final eight teams in the Copa America. Here is the lowdown on each of the four quarterfinal clashes (all live on ESPN+).
The phony war of the Copa America group phase is over. Tim Vickery previews all four quarterfinals, including a very familiar Brazil-Paraguay game.
Copa America organisers said they believe the tournament in Brazil is running smoothly despite empty seats and criticism of the pitches.
Luis Suarez marked the fifth anniversary of biting Giorgio Chiellini by doing Luis Suarez things in Uruguay's Copa America game against Chile.
Chile's coach Reinaldo Rueda did all he could with his ageing squad, but give credit to Uruguay's star duo of Edinson Cavani and Luis Suarez.