- André-Pierre Gignac (27', 66')
- Luis Quiñones (83')
- Jesús Angulo (88')
- Nicolás Ibáñez (90')
2nd Leg - Tigres UANL advance 6-0 on aggregate
3:00 AM, 14 April 2023
San Nicolás de los Garza, Mexico
- Walter Lopez
Match ends, Tigres 5, Motagua 0.
Second Half ends, Tigres 5, Motagua 0.
Goal! Tigres 5, Motagua 0. Nicolás Ibáñez (Tigres) right footed shot from the centre of the box to the bottom right corner. Assisted by Luis Quiñones with a through ball.
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