Der Klassiker did not disappoint, but Barcelona did. Elsewhere, the Simeone family had an up-and-down time and West Ham upset another contender.
Atletico Madrid conceded a goal by Mallorca's Takefusa Kubo in added time in a shock 2-1 LaLiga home defeat on Saturday that will be remembered.
The Slovenia international has been on top for a long time, after a rise that saw inspiration from his family and learning to deal with setbacks.
Atletico Madrid turned around a poor first-half performance to score four goals after the break and earn a 4-1 win at Cadiz on Sunday.
A stunning header from Junior Messias in the dying minutes gave AC Milan a 1-0 win over Atletico Madrid to keep their Champions League hopes alive.
Atletico Madrid's Brazilian defender Felipe hit a late stunner to claim a 1-0 home win against Osasuna in LaLiga on Saturday.
Atletico Madrid Antoine Griezmann scored a sensational goal against Valencia but the visitors let a two-goal lead slip in stoppage time to draw 3-3.
In a game that felt cathartic for the Anfield faithful, Liverpool ensured that Atletico Madrid would not repeat their upset from March 2020.
Liverpool maintained their perfect start to the Champions League with a win over Atletico Madrid at Anfield on Wednesday night.
Atletico Madrid returned to winning ways in LaLiga on Sunday with a dominant 3-0 home victory over Real Betis.
Atletico Madrid conceded a last-minute penalty as they were held to a 2-2 draw by struggling Levante in LaLiga on Thursday.
Luis Suarez scored a second half brace as Atletico Madrid came from two goals down to draw 2-2 at home against LaLiga leaders Real Sociedad.
Mohamed Salah and Antoine Griezmann each netted braces, but while the former led Liverpool to victory, latter was sent off in Atletico's defeat.
Liverpool secured a thrilling 3-2 victory over Atletico Madrid in the Champions League on Tuesday at the Wanda Metropolitano.