Tottenham Hotspur have strongly condemned anti-Semitic chanting that happened ahead of Manchester City's Premier League match against Spurs on Saturday.
Mobile phone footage was filmed on a tram from Manchester city centre to the Etihad Campus shortly before the match kicked off.
Chants related to World War II concentration camps can be heard.
Tottenham's support is historically made up of a large Jewish fan base, and their fans have been subjected to anti-Semitic chants for decades.
"Anti-Semitism in any form is wholly unacceptable and we support all efforts to kick it out of the game," a club spokesperson said.
"We hope that those individuals responsible for this vile behaviour are identified and dealt with in the strongest way possible."
In a statement, Jonathan Arkush, the president of the Board of Deputies of British Jews, said: "Sick racist chanting has been an enduring part of the football scene in this country for far too long now.
"It is a criminal offence. The perpetrators should be arrested and feel the full force of the law."
A spokesman for Manchester City said the club "strongly condemns the use of any anti-Semitic language'' and would cooperate with any investigation.
Superintendent Steve Howard, from the City of Manchester Division, said the Police had begun an investigation.
''Following recent media coverage, Greater Manchester Police have been made aware of a video showing people chanting anti-Semitic songs," he said.
''We believe those involved were heading for the football match between Manchester City and Tottenham.
''This has yet to be formally reported to police. However, we have now launched an investigation and we are treating this as a hate crime.
'We would like to speak to anyone who witnessed the incident or has video footage to contact police as soon as possible.
''There is no place in society for such abhorrent behaviour, and we will not tolerate hate crime of any sort in Greater Manchester.''