Genoa says another 12 members of the match squad have the coronavirus, taking the total number of cases at the Serie A club to 14.
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Hirving Lozano struck twice as Napoli thrashed Genoa 6-0 on Sunday to begin their Serie A campaign with back-to-back victories.
Genoa, Italy's oldest professional club, guaranteed Serie A survival on the final day of the season, while Lecce were relegated to Serie B.
Inter Milan put more pressure on stuttering Serie A leaders Juventus when two goals by Romelu Lukaku helped them to a 3-0 win over Genoa.
Genoa moved closer to safety when they beat neighbours Sampdoria 3-1 in the Lighthouse Derby on Wednesday while Brescia were relegated.
Torino captain Andrea Belotti scored for the seventh game in a row to complete a 3-0 win over relegation-threatened Genoa in Serie A.
Genoa boosted their hopes of Serie A survival with a 2-0 win over bottom-of-the-table SPAL on Sunday, their first win in six games.
A second-half goal from Hirving Lozano gave Napoli a 2-1 win at struggling Genoa in Serie A on Wednesday.
Juventus secured a 3-1 win at lowly Genoa on Tuesday to stay four points clear at the top of Serie A.