United States youth international Cameron Carter-Vickers is set to join Championship club Sheffield United on a season-long loan, sources have told ESPN FC.
Carter-Vickers, 19, made four appearances in the domestic cups last season but he is yet to feature in the Premier League for Spurs.
Last season, Mauricio Pochettino said Carter-Vickers could become "one of the best centre-backs in England" and the Spurs manager has generally been reluctant to send the most promising young players at the club on loan.
But this summer has marked a change in approach and Carter-Vickers' move to the Championship comes after Joshua Onomah joined Aston Villa on loan earlier this month.
Carter-Vickers -- who could be recalled by Spurs in January -- earned a first senior call-up to the U.S. squad in November last year but did not feature in the World Cup qualifiers against Costa Rica or Mexico. He has been a regular for his country at Under-20 and U23 levels.
Sheffield United have started the season with wins and two defeats from four matches in the second tier, and their manager Chris Wilder has used a 3-4-3 system, similar to the one favoured by Pochettino.
Spurs have already signed centre-back Davinson Sanchez for a club-record £36.5 million, while sources have told ESPN FC that they are closing in on the signing of Argentina Under-20 centre-back Juan Foyth.