The Bavarians, who have now scored eight goals in their first two league matches, were lethal in attack, especially in the first half, with Sadio Mane, Muller and Musiala wreaking havoc in their opponents' box.
Mane also put the ball in the net twice more but his efforts were cancelled by VAR reviews for offside.
"It was obviously not the big show of the first two matches [including Bayern's 5-3 Super Cup win over RB Leipzig]," Muller said. The Bavarians had crushed Eintracht Frankfurt 6-1 in their Bundesliga opener last week.
"We struggled a bit in the first 10 minutes. Wolfsburg played a lot of long balls to get out of our pressing. We needed some time but got going and maybe we could have scored one or two more goals."
Alphonso Davies almost scored an own goal when he cleared a header but his effort bounced off the post in the fifth minute, with Wolfsburg enjoying a confident start.
It did not last, however, with Bayern gradually taking control and Germany international Musiala showing great skill and power to shrug off two markers, stay up and drill in for the lead in the 33rd minute.
The 19-year-old Musiala became the first German player under the age of 20 to score 14 Bundesliga goals.
Wolves were soon reduced to desperate attempts at stopping the waves of Bayern attacks but Muller, in his 417th Bundesliga game that lifted him to fourth on the all-time Bayern list, wrongfooted keeper Koen Casteels by stabbing in a Joshua Kimmich shot two minutes before the break.
Wolfsburg, led by former Bayern coach Niko Kovac, rarely had a look-in and managed just one shot on target in the entire game even after Bayern took their foot off the gas in the second half.
"With all due respect Bayern are in a different class," Wolfsburg's Maximilian Arnold said. "We still had a few chances and you have to score when you get them. Then it could be a different game."
Bayern are top of the standings on six points, ahead on goal difference of Borussia Dortmund, who have also won their two league matches so far.