Internazionale's Christian Eriksen scored midway through the second half to set the runaway Serie A leaders on the way to a 2-0 win at Crotone on Saturday that moved them within a point of clinching the title and confirmed their hosts' relegation.
Inter are on 82 points, 14 clear of second-placed Atalanta, and need one point to guarantee a first league title since 2010 due to their superior head-to-head record over the Bergamo club.
However, they will be crowned champions on Sunday if Atalanta fail to win at Sassuolo.
"The season we are having is the result of a constant growth from every point of view, not only technical and tactical, of mentality, sharing, living it intensely," Inter boss Antonio Conte told Sky Italia.
"All the players, even those who are less involved, have created something rock-solid.
"We understood the importance of doing something extraordinary and entering into the history of Inter.
"We are succeeding in toppling a reign that has lasted nine years. These players deserve to be congratulated."
Eriksen's deflected effort four minutes after coming off the bench found the bottom corner in the 69th minute to make the breakthrough and Achraf Hakimi finished a counter-attack to double Inter's lead in stoppage time.
Asked if he had scored the title-winning goal for Inter, Eriksen told Sky Italia: "Not officially, we have to wait for tomorrow. But we are very close to the title.
"I am very happy for the goal. I haven't scored a lot but if this is the Scudetto-winning goal, I will be so happy."
The goal condemned bottom side Crotone to relegation, as Serse Cosmi's side have 18 points, 13 fewer than Cagliari in the safety zone in 17th place with four games remaining.
The move immediately paid off as Lukaku laid a pass into the path of Eriksen four minutes later and the Dane's powerful shot took a deflection on its way into the net.
Lukaku's involvement made him the first player to score 20 or more goals and provide at least 10 assists in a single Serie A season since OPTA started collecting the data in 2004/05.
Perisic came close to extending the lead with a curling shot and the Croatian then set up Lukaku but the Belgian's effort was disallowed for offside.
Hakimi made sure of the points late on by sliding a neat finish under goalkeeper Alex Cordaz to complete a sweeping counter-attack as Inter moved closer to the title.