Bayer Leverkusen slumped to a 2-1 home loss to Freiburg on Sunday to drift further away from a top-four finish and cap a dismal week following their Europa League exit.
Leverkusen, eliminated from the Europa League in midweek after a second defeat to Young Boys, had the lion's share of possession with close to 70% but failed to make that advantage count.
Freiburg stunned the hosts on the break in the 50th minute with Ermedin Demirovic slotting in from a Lucas Hoeler cutback.
Hoeler then tapped in their second goal in the 61st before Leon Bailey's thundering shot from the left in the 70th set up a tense finale where Leverkusen pushed for an equaliser but failed to score.
Peter Bosz's team were top of the table in December but Leverkusen have won just one of their last six league games to drop to sixth place on 37 points, five off fourth place which would secure Champions League football next season.
Freiburg climb up to eighth on 34.