The Espanyol forward opened the scoring in coach Li Tie's first competitive game as head coach and netted his side's third, with Jin Jingdao, Wu Xi and Elkeson also on target before Alan Carvalho's late brace.
Only the group winners are guaranteed to advance to the next round of Asia's preliminaries along with the four runners-up across the eight groups with the best records.
Wu Lei gave the Chinese the lead from the penalty spot in the 20th minute, nonchalantly stroking the ball past Dallas Jaye after being upended in the area by Marlon Evens.
Jin Jingdao doubled China's advantage six minutes before the break when he latched on to Wu Xi's perfectly weighted through ball. Wu Lei claimed his second 10 minutes after the interval, sweeping his effort home after Zhang Xizhe's cut back.
Wu Xi side-footed in from inside the six-yard box in the 61st minute to put China 4-0 up, and Brazil-born Guangzhou FC striker Elkeson added the fifth midway through the half with a powerful downward header.
Carvalho, another of China's naturalised Brazilian players, pushed Zhang Yuning's centre over the line with his thigh six minutes from time and scored his second of the night four minutes later when he headed in Wei Shihao's cross.